Study of Some Hematological Parameters in Offpring of Heperlipidemic Female Laboratory Rats After Slmvastatln Treatment During Lactation

Abstract

The present study was designed to evaluate some of the haematological parameters in offspring of hyperlpidemic female rats after simvastatin treatment during lactation. Twenty four female rat were used in the current study were matted with fertile males, twelve of females are induced for hypercholesterolemia during pregnancy, other twelve were not, all animals were divided into 4 equal groups after delivery: G.1 (Control) normal animals given only 0.5 ml/kg animal of Dimethyl Sulphoxide (DMSO). G.2 hypercholestrolemic animals given only 0.5 ml/ animal of Dimethyl Sulphoxide (DMSO). G.3 (S1) hypercholestrolemic animals treated with 20 mg/kg/day (0.02ml/ animal) of simvastatine . G.4 normal animals treated with 20 mg/kg/day (0.02ml/ animal) of simvastatine.  The treatment of mothers were continued for 30 days after delivery. Offspring (only the  males)of these animals were sacrificed at their puberty and blood samples were collected in EDTA tubes for measuring of some hematological parameters. The present study revealed that a significantly decreased(P?0.05) of  RBC count, hemoglobin concentration (Hb), platelets count and MPV levels in offspring (male and female ) of  G3 and G4 groups treated with simvastatin , except RBC count in G3 were not significantly differ compare with control group. Treatment with statins significantly reduce of some hematological parameters such as RBC, Hb, platelets and MPV in offspring of females rat that treated with these drugs during lactation irrespective of cholesterol levels.