Relationship between serum adiponectin and apelin hormones with lipid profile in Basra pregnant women

Abstract

Pregnancy is associated with normal physiological changes that assist the nurturing and survival of the fetus. Changes in hormonal levels and biochemical levels,  these adaptive changes which become very important in the event of complications. So the study was carried out with the objective to determine the levels of adiponectin and apelin and their relations with lipid profile (TC, TG and HDL) were investigated in present study in groups of Basra pregnant women   during different months of pregnancy and the results were compared with non pregnant females as control group.In this study one hundred sixty healthy women ranging from 20 - 40 years old, out of them seventy pregnant and ninety females non-pregnant were considered as control group. The pregnant women attended the Gynecology units in the public state hospitals in Basra Governorate. The enzyme linked immunosorbent assay system (ELISA) was used to determine the serum apelin and adiponectin levels. Blood samples were taken from pregnant women at the end of each month of pregnancy and from control group. The results indicated that adiponectin and apelin levels decreased significantly (p < 0.0001, p < 0.01) respectively in pregnant women than non- pregnant women.On the other hand, accompanied by an increase significantly (p < 0.0001) in the level of Lipid profile (TC, TG and HDL) concentration in pregnant women compared to non-pregnant women.

 Pearson correlation analysis showed a high significant correlation between serum apelin and serum adiponectin level, in addition to both of them with Lipid profile. The finding suggests that serum apelin and adiponectin besides lipid profile