STUDY THE IMPACT OF ANTIVENOM OF Echis carinatus SNAKE ON BLOOD PARAMETER, ENZYMES AND SEX HORMONES PARAMETERS IN WISTER AlBINO MALE RATS
Keywords:Antivenom, blood parameters, liver enzymes, sex hormone, rats.
In the current study the authors aimed to investigate the effect of anti-venom of Echis carinatus on hematological and hormones parameters as well as explore its influence on liver enzymes of male rats. Mature adult rats were divided into three groups 6 animals for each group. IP injected method was used. First group (Control group) injected with normal saline (0.9%Nacl), Two group injected with (0.25ml/kg) of anti-venom for two times, and the third group injected with (0.5ml/kg) of antivenom for two times. Animals killed within 24 h.
The outcome of the current study showed that there are statistically different in RBC, MCH, MCHC, PCV, MCV, total WBC, lymphocytes, monocytes and granulocytes among second and third groups compared with control group (P?0.05). In addition, the results show a significant increasing the number of platelets and liver enzymes ALT, AST, ALP in the highly-treated group comparing with the control. Also, level of FSH, LH and testosterone likewise increased in the treated groups comparing with control. Anti-venom reduced sperm count in male rats.