Protective role of polyphenolic compounds extracted from cyperus rotundus rhizomes and taurine on troponin-I and some oxidant/antioxidants parameters of female rats treated with isoproterenol – induced myocardial infraction.

Abstract

The present study was designed to investigate the effects of polyphenolic compounds extracted from cyperus rotundus rhizomes and taurine on isoproterenol induced myocardial infraction in female rats. Sixty of female rats (Rattus norvegicus) were used in the present study. Animals were divided into 10 groups ( 6 for each group). MI was induced in rats with ISO (85 mg/kg) twice at an interval of 24 hrs. ISO produced significant alterations in the troponin-I, serum MDA, tissue MDA, Cp, Alb, uric acid, serum GSH and tissue GSH. The effect of polyphenolic compounds from cyperus rotundus rhizomes oral treatment for 21 days at two doses (15 mg and 30 mg/kg, body weight) and taurine at two doses ( 100 mg and 200 mg/kg, body weight) was evaluated against ISO- induced cardiac necrosis. The results showed a significant increase in the level of serum troponin-I,  serum MDA, tissue MDA, Cp and uric acid  in ISO- treated animals as compared with the control animals. While, the results showed asignificant decrease in the level of serum Alb, serum GSH and tissue GSH in ISO- treated animals as compared with the control animals. Polyphenolic compounds from cyperus rotundus rhizomes and taurine showed a significant cardioprotective activity by lowering the levels of serum troponin-I,  serum MDA, tissue MDA, Cp and uric acid and elevate the levels of Alb, serum GSH and tissue GSH. This study concluded that the polyphenolic compounds from cyperus rotundus rhizomes and taurine possess cardioprotective activity against Isoproterenol induced myocardial infraction in rats.